Model Challenge Workshop

The model challenge committee held a weekend workshop on June 20/21 with a selected group of cryoEM specialists and model software developers to share results and develop plans for the model challenge. The outcome of this meeting is the recommendation by this group to launch a community wide challenge to model 5-7 selected cryoEM density maps that have been reported to be determined at 3.0-4.5 Å gold-standard resolution.

EMDataBank Challenges

EMDataBank is hosting community-wide challenges to critically evaluate 3DEM methods that are coming into use, with the ultimate goal of developing recommendations for validation criteria associated with every 3DEM map deposited to the EM Data Bank (EMDB) and map-derived model deposited to Protein Data Bank (PDB). 


Map Challenge

The Blind Assessment Phase is now open (Nov 2016-midFeb 2017).  Please visit the map challenge page for more details.

Model Challenge

The Challenge Phase for the 2015/2016 Model Challenge is now closed. Please visit the model challenge page for more details.


 Three-dimensional Electron Microscopy (3DEM) is becoming a key experimental method in Structural Biology. Recent advances in image acquisition and processing are yielding more structures determined at near-atomic resolution, as well as a wide range of macromolecular complexes and subcellular architectures determined at lower resolution.


A major goal of the EMDataBank team is to work with the 3DEM community to establish data validation methods that can be used in the structure determination process, define key indicators of a well-determined structure that should accompany every structure deposition, and implement appropriate validation procedures into a 3DEM validation pipeline. Following recommendations of the EM Validation Task Force (Henderson et al 2012), we are hosting new benchmark challenges here, with aim to stimulate further community discussions about validation procedures for 3DEM maps and map-derived models. Prior community-organized 3DEM challenge activities have included a Particle Picking Challenge (Zhu et al 2004),  CryoEM Modeling Challenge (Ludtke et al 2012), and CTF Challenge (Marabini et al 2015).

EMDataBank Validation Challenges are supported by NIH National Institute of General Medical Sciences

Please send your challenge questions, comments and feedback to

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