News

JSB Special Issue on Outcomes of the Map and Model Challenges

We are pleased to announce that the Journal of Structural Biology has agreed to produce a special issue on the 2016 Map and Model Challenges.

For those planning to submit a manuscript, here are the particulars:

Joint Challenges Wrap-Up Meeting Oct 6-8

In 2016 EMDataBank ran two community challenges in parallel to create awareness of the need for cryoEM structure validation as a routine process in research studies and publications, and to expedite development of quantitative tools for assessment

Model Challenge Face-to-Face Meeting

Update for the Model Challenge: A face-to-face meeting was held Monday May 29, 2017 to discuss model assessments and how to move forward with completing the challenge.  The challenge has been designed to enable assessment of current approaches to interpretation of higher resolution (3-5Å) cryoEM maps with atomic models, to critically evaluate the map interpretation, model fitting, model refinement, and validation methods that are now coming into use. Initial assessments of the 106 submissions from 16 modellers have been prepared and can be viewed at the model comparison site.  Notes from the May 29 meeting are available in the provided attachment.

Pages

Map Challenge

June 2017: The Blind Assessment Phase has ended and full submission data are now available.  Please visit the map challenge page for more details.

Model Challenge

The full workflow for the 2015/2016 Model Challenge is now available. Please visit the model challenge page for more details.

Welcome

 Three-dimensional Electron Microscopy (3DEM) is becoming a key experimental method in Structural Biology. Recent advances in image acquisition and processing are yielding more structures determined at near-atomic resolution, as well as a wide range of macromolecular complexes and subcellular architectures determined at lower resolution.

 

A major goal of the EMDataBank team is to work with the 3DEM community to establish data validation methods that can be used in the structure determination process, define key indicators of a well-determined structure that should accompany every structure deposition, and implement appropriate validation procedures into a 3DEM validation pipeline. Following recommendations of the EM Validation Task Force (Henderson et al 2012), we are hosting new benchmark challenges here, with aim to stimulate further community discussions about validation procedures for 3DEM maps and map-derived models. Prior community-organized 3DEM challenge activities have included a Particle Picking Challenge (Zhu et al 2004),  CryoEM Modeling Challenge (Ludtke et al 2012), and CTF Challenge (Marabini et al 2015).

EMDataBank Validation Challenges are supported by NIH National Institute of General Medical Sciences

Please send your challenge questions, comments and feedback to challenges@emdatabank.org

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